Selected article for: "respiratory infection and RV respiratory infection"
Author: Claus, Claudia; Manssen, Lena; Hübner, Denise; Roßmark, Sarah; Bothe, Viktoria; Petzold, Alice; Große, Claudia; Reins, Mareen; Mankertz, Annette; Frey, Teryl K.; Liebert, Uwe G.
Title: Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection
  • Document date: 2015_11_26
    • ID: 1rrm4sqa_45
    Snippet: The release of apoptosis-promoting factors upon mitochondrial membrane permeabilization is crucial for the execution of the intrinsic mitochondrial apoptotic pathway. Data presented in this paper highlight mPTP opening and mitochondrial-nuclear translocation of AIF in a minor portion of cells under RV infection. Being released from mitochondria, AIF is a potent apoptosis-promoting factor [34] . Its nuclear translocation is followed by chromatinol.....
    Document: The release of apoptosis-promoting factors upon mitochondrial membrane permeabilization is crucial for the execution of the intrinsic mitochondrial apoptotic pathway. Data presented in this paper highlight mPTP opening and mitochondrial-nuclear translocation of AIF in a minor portion of cells under RV infection. Being released from mitochondria, AIF is a potent apoptosis-promoting factor [34] . Its nuclear translocation is followed by chromatinolysis and DNA fragmentation. However, the contribution of AIF and cyclophilins to RV-associated cell death appears to be negligible as indicated by the minor effect exerted by NIM811 on RV floater population or on selected markers for apoptosis. The observed release of CytC could help to explain the reported reduction of mitochondrial respiratory chain complex IV activity during RV infection [12] .

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