Selected article for: "global burden and novel vaccine"
Author: Shi, Ting; McLean, Kenneth; Campbell, Harry; Nair, Harish
Title: Aetiological role of common respiratory viruses in acute lower respiratory infections in children under five years: A systematic review and meta–analysis
  • Document date: 2015_6_17
    • ID: 13cotyfb_22
    Snippet: These findings should inform the results of studies which seek to estimate the global / regional / national burden of disease due to these viruses. They support the role of RSV, IFV, PIV and MPV as important causes of ALRI in young children (although disease burden estimates should take into account the AFE estimates that we report -thus the true global burden of RSV/IFV/PIV/MPV pneumonia may be 90%/80%/70%/73% of the values reported in recent Ta.....
    Document: These findings should inform the results of studies which seek to estimate the global / regional / national burden of disease due to these viruses. They support the role of RSV, IFV, PIV and MPV as important causes of ALRI in young children (although disease burden estimates should take into account the AFE estimates that we report -thus the true global burden of RSV/IFV/PIV/MPV pneumonia may be 90%/80%/70%/73% of the values reported in recent Table 2 . The meta analyses of the odds ratios (OR) and attributable fraction in the exposed (AFE) of each virus and its subtype within included studies of inpatient (IP) ALRI cases relative to asymptomatic controls ViruS metA AnAlySeS* SenSitiVity AnAlySeS* publications). Applying these estimates to the burden of severe (hospitalised) pneumonia in 2010 [38] , we estimate that the likely true burden of RSV and influenza associated ALRI for that year would be about 2.9 (95% CI 1.5-5.5) million and 0.8 (0.3-2.2) million respectively. There is considerable international attention on RSV and IFV pneumonia in young children at this time when novel vaccine strategies are being evaluated and prioritised and more accurate disease burden estimates (using these results) would help inform future policies and interventions.

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