Selected article for: "alveolar macrophage and gene expression"
Author: Meliopoulos, Victoria A.; Van de Velde, Lee-Ann; Van de Velde, Nicholas C.; Karlsson, Erik A.; Neale, Geoff; Vogel, Peter; Guy, Cliff; Sharma, Shalini; Duan, Susu; Surman, Sherri L.; Jones, Bart G.; Johnson, Michael D. L.; Bosio, Catharine; Jolly, Lisa; Jenkins, R. Gisli; Hurwitz, Julia L.; Rosch, Jason W.; Sheppard, Dean; Thomas, Paul G.; Murray, Peter J.; Schultz-Cherry, Stacey
Title: An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens
  • Document date: 2016_8_9
    • ID: 16e99fuz_17
    Snippet: Sorting autofluorescent CD11c + CD11b -AM from uninfected WT mice and comparing them by microarray to autofluorescent CD11c + CD11b + 'AM' from β6 KO demonstrated that Table 1 ). There was no difference in IDO1 expression, a cardinal IFN-γ regulated gene [48] ( Table 1) . These data suggest lung macrophages in the absence of β6 had increased IFN signaling. To test this further, we measured phosphorylation of IRF3 and STAT1, hallmarks of the ty.....
    Document: Sorting autofluorescent CD11c + CD11b -AM from uninfected WT mice and comparing them by microarray to autofluorescent CD11c + CD11b + 'AM' from β6 KO demonstrated that Table 1 ). There was no difference in IDO1 expression, a cardinal IFN-γ regulated gene [48] ( Table 1) . These data suggest lung macrophages in the absence of β6 had increased IFN signaling. To test this further, we measured phosphorylation of IRF3 and STAT1, hallmarks of the type I IFN response, in the alveolar macrophage populations from WT and β6 KO mice. CD11c + CD11b + macrophages from uninfected β6 KO mice had increased phospho-IRF3 and phospho-STAT1 relative to WT CD11c + CD11b -AM ( Fig 8F) .

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