Selected article for: "IFN Î level and viral replication"
Author: Wang, Kai; Ran, Ling; Yan, Tao; Niu, Zheng; Kan, Zifei; Zhang, Yiling; Yang, Yang; Xie, Luyi; Huang, Shilei; Yu, Qiuhan; Wu, Di; Song, Zhenhui
Title: Anti-TGEV Miller Strain Infection Effect of Lactobacillus plantarum Supernatant Based on the JAK-STAT1 Signaling Pathway
  • Document date: 2019_11_6
    • ID: 05tf6oqa_56
    Snippet: In addition, although TGEV delayed the expression of IFN-β in the early stage of infection, it promoted the expression of IFN-β at the peak of viral replication. The expression of IFN-β was parallel to the increase of viral RNA replication level at 24-48h, which demonstrated that TGEV replication remained high in the late stage of infection when IFN-β was produced in large quantities. This might be caused by the inhibitory effect of TGEV on I.....
    Document: In addition, although TGEV delayed the expression of IFN-β in the early stage of infection, it promoted the expression of IFN-β at the peak of viral replication. The expression of IFN-β was parallel to the increase of viral RNA replication level at 24-48h, which demonstrated that TGEV replication remained high in the late stage of infection when IFN-β was produced in large quantities. This might be caused by the inhibitory effect of TGEV on IFN-β-mediated signaling pathways, resulting in the inability of IFN-β to regulate the transcription and expression of downstream target cytokines and exert an antiviral role.

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