Antibody Engineering for Pursuing a Healthier Future

Saeed, Abdullah F. U. H.; Wang, Rongzhi; Ling, Sumei; Wang, Shihua

Biopanning in vivo with phage display libraries has facilitated the isolation of peptides homing to all types of organs in the human body. Phage display is applied to stem cells for cell based regenerative medicine (Gothard et al., 2011) . Moreover, this technique has assisted in the guided delivery of various peptides/drugs such as proapoptotic peptides, cytotoxic drugs, metalloprotease inhibitors, and cytokines to specific targets (Nixon et al., 2014) . The binding of peptides with the extracellular domain of the LOX-1 receptor is associated with hypertension and atherogenesis (Nixon et al., 2014) . Other studies have reported that the homing of an RGD-motif-containing peptide to angiogenic vasculature was linked to a proapoptotic peptide and was successfully used for the treatment of collagen-induced arthritis in mice. Phage libraries have also been used for antiobesity, microparticle (MP), avb3 integrin angiogenesis therapy, and in targeting vascular endothelial growth factor (VEGF) (Cooke et al., 2001) .