Author: Zhai, Xiaofeng; Wang, Shilei; Zhu, Mengyan; He, Wei; Pan, Zhongzhou; Su, Shuo
Title: Antiviral Effect of Lithium Chloride and Diammonium Glycyrrhizinate on Porcine Deltacoronavirus In Vitro Document date: 2019_9_9
ID: 1m5yr8uc_32
Snippet: PDCoV infection can cause vomiting and watery diarrhea in piglets and seriously damage the growth of the pig industry. Until now, there are no records of clinically effective agents for the treatment of PDCoV infection, and no compound has shown antiviral activity [35] . Therefore, there is an urgent need to develop a good approach for preventing PDCoV infection. Because neither specific antiviral drugs nor vaccines are available for newly emergi.....
Document: PDCoV infection can cause vomiting and watery diarrhea in piglets and seriously damage the growth of the pig industry. Until now, there are no records of clinically effective agents for the treatment of PDCoV infection, and no compound has shown antiviral activity [35] . Therefore, there is an urgent need to develop a good approach for preventing PDCoV infection. Because neither specific antiviral drugs nor vaccines are available for newly emerging viruses and it is not possible to develop small-molecule drugs and vaccines that act on PDCoV in a short period of time, the novel use of traditional drugs has long been considered to be an important means of finding new therapies targeting new infectious diseases [36] . It has been reported that LiCl and DG, which are often deemed broad-spectrum antiviral reagents, have antiviral properties against coronaviruses such as SARS-CoV, IBV, and PEDV. However, it remains unknown whether LiCl or DG has an inhibitory effect on PDCoV infection.
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