Author: Carabineiro, Sónia Alexandra Correia
Title: Applications of Gold Nanoparticles in Nanomedicine: Recent Advances in Vaccines † Document date: 2017_5_22
ID: 0nz0qioh_67
Snippet: Escherichia coli as a model pathogen for the design of an antibacterial vaccine [132] . The bacterial outer membrane vesicles were collected and successfully coated onto gold nanoparticles with a 30 nm diameter. The resulting bacterial membrane-coated gold nanoparticles, when injected subcutaneously, induced rapid activation and maturation of dendritic cells in the lymph nodes of the vaccinated mice, generated durable antibody responses, and indu.....
Document: Escherichia coli as a model pathogen for the design of an antibacterial vaccine [132] . The bacterial outer membrane vesicles were collected and successfully coated onto gold nanoparticles with a 30 nm diameter. The resulting bacterial membrane-coated gold nanoparticles, when injected subcutaneously, induced rapid activation and maturation of dendritic cells in the lymph nodes of the vaccinated mice, generated durable antibody responses, and induced a high production of interferon gamma and interleukin-17, but not interleukin-4, indicating its capability of generating strong Th1-and Th17-biased cell responses against the used bacteria.
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