Author: Hashem, Anwar M.; Flaman, Anathea S.; Farnsworth, Aaron; Brown, Earl G.; Van Domselaar, Gary; He, Runtao; Li, Xuguang
Title: Aurintricarboxylic Acid Is a Potent Inhibitor of Influenza A and B Virus Neuraminidases Document date: 2009_12_17
ID: 13bvkj2t_27
Snippet: To examine the prophylactic potential of ATA against influenza A infection, MDCK cells were exposed to ATA 24 h prior to viral infection. The cell viability was then assessed by measuring neutral red uptake. We found that pre-exposing MDCK cells to ATA 24 h prior to infection did not protect cells from virus-induced CPE (data not shown). Collectively, these data suggest that ATA is a potent anti-influenza agent with relatively low toxicity in tis.....
Document: To examine the prophylactic potential of ATA against influenza A infection, MDCK cells were exposed to ATA 24 h prior to viral infection. The cell viability was then assessed by measuring neutral red uptake. We found that pre-exposing MDCK cells to ATA 24 h prior to infection did not protect cells from virus-induced CPE (data not shown). Collectively, these data suggest that ATA is a potent anti-influenza agent with relatively low toxicity in tissue culture, as demonstrated by the SI value of 88.8.
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