Selected article for: "display technology and phage display technology"
Author: Frenzel, André; Hust, Michael; Schirrmann, Thomas
Title: Expression of Recombinant Antibodies
  • Document date: 2013_7_29
    • ID: 06o7pa3d_56
    Snippet: In recent years the idea of expressing human antibodies in transgenic animals has increased. On the one hand the humanization of antibodies for therapeutics derived from hybridoma technology is still a laborious and time-consuming procedure which often requires the generation and characterization of a set of different humanized versions of the antibody. On the other hand the mouse or rat derived antibodies may elicit an immune response in patient.....
    Document: In recent years the idea of expressing human antibodies in transgenic animals has increased. On the one hand the humanization of antibodies for therapeutics derived from hybridoma technology is still a laborious and time-consuming procedure which often requires the generation and characterization of a set of different humanized versions of the antibody. On the other hand the mouse or rat derived antibodies may elicit an immune response in patients (225, 226) . One method for the generation of fully human binders is the antibody phage display technology (21).

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