Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects Document date: 2016_10_24
ID: 09tcnsxv_41
Snippet: Only 112 transcripts were found to be significantly regulated between all three samples compared to WT (Fig. 4a) . However, they showed a very different expression profile (Fig. 4d) . Interestingly, IFNAR-deficient astrocytes showed lower levels of PRR, innate immune signaling, transcription factors, ISGs, and adaptive immune response compared to untreated WT astrocytes, whereas, IFNαB/D-and supernatant-treated WT astrocytes showed an upregulate.....
Document: Only 112 transcripts were found to be significantly regulated between all three samples compared to WT (Fig. 4a) . However, they showed a very different expression profile (Fig. 4d) . Interestingly, IFNAR-deficient astrocytes showed lower levels of PRR, innate immune signaling, transcription factors, ISGs, and adaptive immune response compared to untreated WT astrocytes, whereas, IFNαB/D-and supernatant-treated WT astrocytes showed an upregulated profile (Fig. 4d , Additional file 1: Table S2 ).
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