Selected article for: "antiviral signaling and infection outcome"
Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects
  • Document date: 2016_10_24
    • ID: 09tcnsxv_56
    Snippet: Predicting upstream regulators responsible for the different expression patterns in IFNAR −/− -, supernatant-, and IFNαB/D-treated astrocytes identified type I IFN as well as IFN signaling molecules to have the highest activation scores. Similar findings were found in a previous study where IFN signaling and antiviral mediators were among the most upregulated pathways and genes in WNV-infected mice brains [51] . IFNγ-STAT1-IRF-1 signaling c.....
    Document: Predicting upstream regulators responsible for the different expression patterns in IFNAR −/− -, supernatant-, and IFNαB/D-treated astrocytes identified type I IFN as well as IFN signaling molecules to have the highest activation scores. Similar findings were found in a previous study where IFN signaling and antiviral mediators were among the most upregulated pathways and genes in WNV-infected mice brains [51] . IFNγ-STAT1-IRF-1 signaling cascade was predicted as an upstream regulator both in supernatant and IFNαB/D-treated astrocytes. Although IFNγ transcripts were not detected in TBEV infected, astrocytes IRF-1 could be directly induced by virus infection and could be responsible for the induction of the overlap between inducible genes among the type I and II IFNs [79, [82] [83] [84] . Taken together, the RNAseq confirms the potent IFN response of the astrocytes and identifies a subset of genes as key players in determining the outcome of TBEV infection in astrocytes.

    Search related documents:
    Co phrase search for related documents
    • activation score and type ifn: 1
    • antiviral mediator and type ifn: 1, 2, 3, 4, 5
    • astrocytes IFN response and tbev infection: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • astrocytes IFN response and type ifn: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • directly induce and previous study: 1, 2, 3
    • directly induce and tbev infection: 1
    • directly induce and type ifn: 1, 2
    • expression pattern and previous study: 1
    • expression pattern and similar finding: 1, 2
    • expression pattern and tbev infection: 1
    • expression pattern and type ifn: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • gene subset and type ifn: 1
    • gene upregulated pathway and type ifn: 1
    • IFN response and previous study: 1, 2, 3, 4, 5, 6, 7
    • IFN response and signal cascade: 1, 2
    • IFN response and tbev infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • IFN response and type ifn: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • IFN response and type inducible gene: 1, 2
    • IFN signal and type ifn: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25