Author: Hunt, Catherine L.; Lennemann, Nicholas J.; Maury, Wendy
Title: Filovirus Entry: A Novelty in the Viral Fusion World Document date: 2012_2_7
ID: 1j9zmuub_18
Snippet: Early studies found that surface expression of some integrins was down regulated upon transfection of full-length EBOV GP [15, 55, 56] . In addition, EBOV GP-mediated pseudovirion entry is reduced by either antibodies targeting β1 integrins or a soluble form of β1 integrins [56] . These characteristics suggested that one or more integrin subunits might serve as receptors for filoviruses. However, no direct interaction between any portion of EBO.....
Document: Early studies found that surface expression of some integrins was down regulated upon transfection of full-length EBOV GP [15, 55, 56] . In addition, EBOV GP-mediated pseudovirion entry is reduced by either antibodies targeting β1 integrins or a soluble form of β1 integrins [56] . These characteristics suggested that one or more integrin subunits might serve as receptors for filoviruses. However, no direct interaction between any portion of EBOV GP and a member of the β1 integrin family has been identified. More recent studies implicate β1 integrin in stimulation of endosomal protease events that are required for productive EBOV transduction, thus reducing the likelihood of β1 integrins serving as bona fide filoviral receptors [57] .
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