Gaining Insights into the Codon Usage Patterns of TP53 Gene across Eight Mammalian Species

Mazumder, Tarikul Huda; Chakraborty, Supriyo

We have performed a neighbor joining tree analysis based on Kimura 2-parameter (K2P) distances of the coding sequences in TP53 gene across mammalian species (Fig. 4) . We observed that codon usage patterns in TP53 genes have significant similarities among the closely related mammalian species. The gene TP53 in H. sapiens showed resemblance to the TP53 gene in M. mulatta, Similarly, TP53 of F. catus resembled to that of C. lupus and M.unguiculatus with R. norvigicus. Generally, genes with similar functions exhibit similar patterns of codon usage frequency [36] . Our analysis further suggested that the coding sequence of TP53 gene share similar patterns of codon usage bias across eight mammalian species.