Author: Franzo, Giovanni; Cecchinato, Mattia; Tosi, Giovanni; Fiorentini, Laura; Faccin, Francesca; Tucciarone, Claudia Maria; Trogu, Tiziana; Barbieri, Ilaria; Massi, Paola; Moreno, Ana
Title: GI-16 lineage (624/I or Q1), there and back again: The history of one of the major threats for poultry farming of our era Document date: 2018_12_20
ID: 0pi042qi_28
Snippet: Other studies have demonstrated the presence of relevant biological variations even within the same genotype [39] ; the circulation of strains with peculiar pathogenic features could consequently be advocated. Remarkably, recent Italian and South American strains significantly differ in at least three protein positions (i.e. 47, 52 and 99 of the considered region). Interestingly, amino-acid in position 47 of South American strain was identical to.....
Document: Other studies have demonstrated the presence of relevant biological variations even within the same genotype [39] ; the circulation of strains with peculiar pathogenic features could consequently be advocated. Remarkably, recent Italian and South American strains significantly differ in at least three protein positions (i.e. 47, 52 and 99 of the considered region). Interestingly, amino-acid in position 47 of South American strain was identical to the one featuring the ancient, and clinically relevant, Italian strains (S3 Fig) [46] . Even if suggestive, more detailed studied based on a reverse genetic approach will be useful to elucidate the actual influence of these residues on GI-16 virulence.
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