Author: Cong, Wei; Zhang, Xiao-Xuan; He, Jun-Jun; Li, Fa-Cai; Elsheikha, Hany M.; Zhu, Xing-Quan
Title: Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection Document date: 2017_3_10
ID: 05tshufp_18
Snippet: In conclusion, these findings provided new insight regarding the ability of T. gondii to alter the expression of 82 microRNAs in cat liver. Our study revealed that through reprogramming of hepatic miRNAs expression T. gondii influences the cellular microenvironment and host anti-T. gondii response, which are likely to play roles in the parasite pathogenesis. GO analysis revealed that the predicted targets of the differentially expressed miRNAs we.....
Document: In conclusion, these findings provided new insight regarding the ability of T. gondii to alter the expression of 82 microRNAs in cat liver. Our study revealed that through reprogramming of hepatic miRNAs expression T. gondii influences the cellular microenvironment and host anti-T. gondii response, which are likely to play roles in the parasite pathogenesis. GO analysis revealed that the predicted targets of the differentially expressed miRNAs were involved in the regulation of cell cycle and most of the identified KEGG pathways were related to cancer. Considering the immunoregulatory effects of miRNAs and their ability to
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