Author: Zheng, Yueming; Zhu, Xuejing; Zhou, Pingzheng; Lan, Xi; Xu, Haiyan; Li, Min; Gao, Zhaobing
Title: Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants Document date: 2012_12_12
ID: 1manzf3l_14
Snippet: Structurally, HCP is distinct from all previously reported KCNQ1 or KCNQ1/KCNE1 activators (Fig. 1) . To obtain a better understanding for HCP activity on KCNQ channels, we examined its effects on KCNQ1, KCNQ1/KCNE1, KCNQ2, KCNQ3, KCNQ2/3 and KCNQ4 isoforms by electrophysiology. To elicit the currents, a fixed 210 mV depolarization was used for all tested channels. Table 1 summarizes 10 mM HCP potentiation on the indicated outward currents. HCP p.....
Document: Structurally, HCP is distinct from all previously reported KCNQ1 or KCNQ1/KCNE1 activators (Fig. 1) . To obtain a better understanding for HCP activity on KCNQ channels, we examined its effects on KCNQ1, KCNQ1/KCNE1, KCNQ2, KCNQ3, KCNQ2/3 and KCNQ4 isoforms by electrophysiology. To elicit the currents, a fixed 210 mV depolarization was used for all tested channels. Table 1 summarizes 10 mM HCP potentiation on the indicated outward currents. HCP potentiates all tested channels except KCNQ3 (Fig. 2) . Noticeably, HCP significantly potentiates both KCNQ1 and the KCNQ1/KCNE1 complex. The I/I 0 values were 1.4860.13 and 4.4760.70, respectively. The effects of HCP on G-V curves of these subtypes were examined and summarized in Table 1 . The unique subtype selectivity, i.e., strong
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