Author: Marcotullio, Maria Carla; Pelosi, Azzurra; Curini, Massimo
Title: Hinokinin, an Emerging Bioactive Lignan Document date: 2014_9_17
ID: 04kh4yzy_31
Snippet: In light of the interesting biological activities of hinokinin (1) and its potential use as therapeutic agent, it is important to investigate its mutagenic and genotoxic activities. Recently Resende et al. used the Ames and Comet assays, to assess the safety of using hinokinin as a drug [99] . In the Comet assay, on Chinese hamster lung fibroblasts (V79), hinokinin was shown to not be genotoxic. In the treatments with hinokinin associated with th.....
Document: In light of the interesting biological activities of hinokinin (1) and its potential use as therapeutic agent, it is important to investigate its mutagenic and genotoxic activities. Recently Resende et al. used the Ames and Comet assays, to assess the safety of using hinokinin as a drug [99] . In the Comet assay, on Chinese hamster lung fibroblasts (V79), hinokinin was shown to not be genotoxic. In the treatments with hinokinin associated with the known mutagen doxorubicin (DXR), the lower concentrations of 1 (0.5; 1.0 and 2.0 μM) significantly reduce DXR-induced DNA damage. The reduction in the DNA damage frequency ranged from 60.8% to 76.0% and it is not dose dependent.
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