Author: Bekpen, Cemalettin; Tautz, Diethard
Title: Human core duplicon gene families: game changers or game players? Document date: 2019_9_16
ID: 0fjh10v7_10
Snippet: In a yeast two-hybrid system, NBPF11 was shown to interact with Chibby, which is a negative regulator of the Wnt signaling pathway [35] . There are currently no data supporting a possible specific molecular function for Olduvai domains in humans. In mouse, targeted deletion of the Olduvai domain in the Pde4dip gene resulted in not only significantly reduced fecundity and hyperactivity of mice but also in physiological changes and liver function-r.....
Document: In a yeast two-hybrid system, NBPF11 was shown to interact with Chibby, which is a negative regulator of the Wnt signaling pathway [35] . There are currently no data supporting a possible specific molecular function for Olduvai domains in humans. In mouse, targeted deletion of the Olduvai domain in the Pde4dip gene resulted in not only significantly reduced fecundity and hyperactivity of mice but also in physiological changes and liver function-related effects [36] .
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