Author: Pattyn, Els; Verhee, Annick; Uyttendaele, Isabel; Piessevaux, Julie; Timmerman, Evy; Gevaert, Kris; Vandekerckhove, Joël; Peelman, Frank; Tavernier, Jan
Title: HyperISGylation of Old World Monkey ISG15 in Human Cells Document date: 2008_6_18
ID: 1eksm537_15
Snippet: We next replaced the differing amino acids in HuISG15 by their AgmISG15 counterparts (see Figure 1 and 4). Four of these residues (i.e. residues 89, 113, 114 and 133) are situated near the interaction interface between ISG15 and its Activating enzyme, UbE1L, predicted by Narasimhan et al. [35] (red highlighted in Figure 4 ). The N83S and S94N allelic variants of HuISG15 were also included. Both conjugation to various UbcHs and total ISGylation pa.....
Document: We next replaced the differing amino acids in HuISG15 by their AgmISG15 counterparts (see Figure 1 and 4). Four of these residues (i.e. residues 89, 113, 114 and 133) are situated near the interaction interface between ISG15 and its Activating enzyme, UbE1L, predicted by Narasimhan et al. [35] (red highlighted in Figure 4 ). The N83S and S94N allelic variants of HuISG15 were also included. Both conjugation to various UbcHs and total ISGylation patterns of different HuISG15 mutants were tested.
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