Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis

Smith, Steven B.; Dampier, William; Tozeren, Aydin; Brown, James R.; Magid-Slav, Michal

Coagulation Factor III (F3). F3 normally binds to the native cofactor VII or VIIa to induce the blood coagulation cascade. Treatment with recombinant coagulation factor VIIa promotes blood coagulation in hemophiliacs [29] [30] [31] . Esmon et al. [68] suggest that coagulation could be used therapeutically to modulate inflammation responses and vice versa, but also caution about the danger of increased incidence of thrombosis. The consistent upregulation of F3 across five viruses suggests that the immunecoagulation axis is already initiated and supplemental F3 activation may cause thrombosis complications. Further study is needed to develop therapeutics that could balance between innate immune response triggered by coagulation factor VIIa therapy and stabilization of the antithrombotic state.