Author: Vojo Deretic; Graham S Timmins
Title: Azithromycin and ciprofloxacin have a chloroquine-like effect on respiratory epithelial cells Document date: 2020_3_31
ID: i4ijuk36_3
Snippet: Here, we report that AZT and ciprofloxacin (CPX), as has been previously demonstrated for chloroquine 26 alter the pH within the intracellular organelles in respiratory epithelial cells, and that this correction results in a normalization of the cell-autonomous immune functions of respiratory epithelia in CF. This effect can be achieved by a diverse set of FDA approved drugs [26] [27] [28] [29] [30] [31] . Our data indicate that AZT's action at l.....
Document: Here, we report that AZT and ciprofloxacin (CPX), as has been previously demonstrated for chloroquine 26 alter the pH within the intracellular organelles in respiratory epithelial cells, and that this correction results in a normalization of the cell-autonomous immune functions of respiratory epithelia in CF. This effect can be achieved by a diverse set of FDA approved drugs [26] [27] [28] [29] [30] [31] . Our data indicate that AZT's action at least in part overlaps with CQ's mode of action. We furthermore propose that clinical trials with patients at risk of developing severe COVID-19, where drugs with deacidifying action such as chloroquine are planned, warrant consideration of CPX,
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