Selected article for: "gene therapy trial and protective vaccine"
Author: Metzger, Vincent T.; Lloyd-Smith, James O.; Weinberger, Leor S.
Title: Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies
  • Document date: 2011_3_17
    • ID: 0gt21051_11
    Snippet: Strikingly, TIP intervention reduces disease prevalence and incidence more effectively than either widespread ART or a 30% or 50% protective vaccine against HIV/AIDS (Figure 2a-b) . The least effective TIP analyzed-which reduces HIV in vivo viral load by 0.5-Log (from 10 5 to 10 4.5 copies/mL)-leads to a reduction in HIV/AIDS prevalence from 29% to 6.5% in 50 years, despite initial deployment to only 1% of individuals while a TIP that generates a.....
    Document: Strikingly, TIP intervention reduces disease prevalence and incidence more effectively than either widespread ART or a 30% or 50% protective vaccine against HIV/AIDS (Figure 2a-b) . The least effective TIP analyzed-which reduces HIV in vivo viral load by 0.5-Log (from 10 5 to 10 4.5 copies/mL)-leads to a reduction in HIV/AIDS prevalence from 29% to 6.5% in 50 years, despite initial deployment to only 1% of individuals while a TIP that generates a 1.5-Log decrease in HIV viral-load-as transiently achieved in a Phase-I clinical trial for an HIV gene-therapy [17] would reduce HIV/AIDS prevalence from 29% to below 1% prevalence in 30 years (Figure 2a) . In comparison, a 30%

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