Author: Natalia Fintelman-Rodrigues; Carolina Q. Sacramento; Carlyle Ribeiro Lima; Franklin Souza da Silva; André C. Ferreira; Mayara Mattos; Caroline S. de Freitas; Vinicius Cardoso Soares; Suelen da Silva Gomes Dias; Jairo R. Temerozo; Milene Miranda; Aline R. Matos; Fernando A. Bozza; Nicolas Carels; Carlos Roberto Alves; Marilda M. Siqueira; Patrícia T. Bozza; Thiago Moreno L. Souza
Title: Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production Document date: 2020_4_5
ID: 6zk0ioep_25
Snippet: Highly pathogenic respiratory viruses, such as influenza A virus, have been associated with a cytokine storm that describes an uncontrolled pro-inflammatory cytokine response 38, 39 . Cytokine storms also seem to be highly relevant for pathogenic human CoVs 40 . Contemporary investigations on SARS-CoV-2 strongly suggest the involvement of cytokine storm with disease severity 22 . COVID-19 mortality is associated with enhanced IL-6 levels and cons.....
Document: Highly pathogenic respiratory viruses, such as influenza A virus, have been associated with a cytokine storm that describes an uncontrolled pro-inflammatory cytokine response 38, 39 . Cytokine storms also seem to be highly relevant for pathogenic human CoVs 40 . Contemporary investigations on SARS-CoV-2 strongly suggest the involvement of cytokine storm with disease severity 22 . COVID-19 mortality is associated with enhanced IL-6 levels and consistent cell death, as measured by LDH . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.04.020925 doi: bioRxiv preprint 1 0 release 22 . We showed that ATV and ATV/RTV decreased IL-6 release in SARS-CoV-2infected human primary monocytes. Moreover, we also included in our analysis TNF-α, another hallmark of inflammation during respiratory virus infections 22, 41 . Our results reveled that cellular mortality and cytokine storm-associated mediators were reduced after treatment with the repurposed antiretroviral drugs used in this study.
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