Selected article for: "cholesterol metabolism and lipid metabolism"
Author: Leclercq, Loïc
Title: Interactions between cyclodextrins and cellular components: Towards greener medical applications?
  • Document date: 2016_12_7
    • ID: 16pzlvzz_59
    Snippet: In 2015, Montecucco et al. reported the anti-atherosclerotic action of KLEPTOSE ® CRYSMEB (a mixture of methylated β-CD where 2-O-methylations are dominant) in atherosclerotic mouse models [131] . As expected, their interfering action with cholesterol metabolism has a positive impact on atherogenesis, lipid profile and atherosclerotic plaque inflammation. In addition to reduce triglyceride serum levels, this CD reduces cholesterol accumulation .....
    Document: In 2015, Montecucco et al. reported the anti-atherosclerotic action of KLEPTOSE ® CRYSMEB (a mixture of methylated β-CD where 2-O-methylations are dominant) in atherosclerotic mouse models [131] . As expected, their interfering action with cholesterol metabolism has a positive impact on atherogenesis, lipid profile and atherosclerotic plaque inflammation. In addition to reduce triglyceride serum levels, this CD reduces cholesterol accumulation in atherosclerotic plaques by the modification of HDL-cholesterol levels. It is noteworthy that HDL and apolipoprotein A-I (ApoA-I) cause a dose-dependent reduction in the activation of CD11b (i.e., anti-inflammatory effect on monocytes) through interactions with several receptors and ABCA1 for HDL and ApoA-I, respectively.

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