Author: Suddala, Krishna C.; Lee, Christine C.; Meraner, Paul; Marin, Mariana; Markosyan, Ruben M.; Desai, Tanay M.; Cohen, Fredric S.; Brass, Abraham L.; Melikyan, Gregory B.
Title: Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes Document date: 2019_1_14
ID: 15wxk8lt_15
Snippet: Virus endosomal trafficking pathways define resistance to IFITM3 compared to control cells. The slower redistribution of SP-DiI 18 to endosomes enriched in IFITM3-imTFP1 is consistent with our previous conclusion that these events represent IAV hemifusion but not full fusion [30] . Indeed, lipid diffusion through both leaflets of a fusion pore is expected to be faster than diffusion through contacting leaflets of a hemifusion intermediate [49] . .....
Document: Virus endosomal trafficking pathways define resistance to IFITM3 compared to control cells. The slower redistribution of SP-DiI 18 to endosomes enriched in IFITM3-imTFP1 is consistent with our previous conclusion that these events represent IAV hemifusion but not full fusion [30] . Indeed, lipid diffusion through both leaflets of a fusion pore is expected to be faster than diffusion through contacting leaflets of a hemifusion intermediate [49] . In another example, IAV SP-DiI 18 dequenching can also occur with a bi-phasic increase in intensity, suggesting either transient fusion pore closure or representing the transition from a restrictive hemifusion structure that attenuates lipid diffusion to a fusion pore (S2 Fig).
Search related documents:
Co phrase search for related documents- fusion pore and transient fusion pore: 1
Co phrase search for related documents, hyperlinks ordered by date