Author: Kumar, Satyendra; Arankalle, Vidya A.
Title: Intracranial Administration of P Gene siRNA Protects Mice from Lethal Chandipura Virus Encephalitis Document date: 2010_1_7
ID: 1mzq227n_55
Snippet: To assess the specificity, inhibition of CHPV replication in P-2 and M-5/M-6 siRNA treated cells was assessed by G gene and P gene-based real time PCRs respectively (data not shown). In both cases, 2logs reduction was recorded. This may reflect the possibility of these siRNAs not only targeting their cognate mRNA but also the positive (+) strand pre-genomic RNA thus affecting overall replication of the virus......
Document: To assess the specificity, inhibition of CHPV replication in P-2 and M-5/M-6 siRNA treated cells was assessed by G gene and P gene-based real time PCRs respectively (data not shown). In both cases, 2logs reduction was recorded. This may reflect the possibility of these siRNAs not only targeting their cognate mRNA but also the positive (+) strand pre-genomic RNA thus affecting overall replication of the virus.
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