Author: Kun Sun; Liuqi Gu; Li Ma; Yunfeng Duan
Title: Atlas of ACE2 gene expression in mammals reveals novel insights in transmission of SARS-Cov-2 Document date: 2020_3_31
ID: 89sg0cpk_34
Snippet: However, we showed that in ACE2 proteins, mice and rats are the only mammals that have different amino acids in the two virus-binding hotspots from humans, which is consistent with previous in vitro virus infection experiments 2 . Moreover, ACE2 was barely expressed in any of the cell types in murine lungs. Thus, both observations argue against using mice as the optimal animal model for studying coronavirus related diseases......
Document: However, we showed that in ACE2 proteins, mice and rats are the only mammals that have different amino acids in the two virus-binding hotspots from humans, which is consistent with previous in vitro virus infection experiments 2 . Moreover, ACE2 was barely expressed in any of the cell types in murine lungs. Thus, both observations argue against using mice as the optimal animal model for studying coronavirus related diseases.
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