Author: Hermesh, Tamar; Moltedo, Bruno; López, Carolina B.; Moran, Thomas M.
Title: Buying Time—The Immune System Determinants of the Incubation Period to Respiratory Viruses Document date: 2010_11_18
ID: 0yqv2osb_49
Snippet: In vivo, lung secreted cytokines and chemokines also promote systemic awareness to the virus infection. Type I IFNs can signal to developing leukocytes and memory T cells in primary and secondary lymphoid organs such as the bone marrow and spleen to acquire an anti-viral state and enhance their function [117, 118] . Such an anti-viral state is thought to functionally improve cells of the immune system before they infiltrate the lungs. Type III IF.....
Document: In vivo, lung secreted cytokines and chemokines also promote systemic awareness to the virus infection. Type I IFNs can signal to developing leukocytes and memory T cells in primary and secondary lymphoid organs such as the bone marrow and spleen to acquire an anti-viral state and enhance their function [117, 118] . Such an anti-viral state is thought to functionally improve cells of the immune system before they infiltrate the lungs. Type III IFNs are also induced after respiratory virus infection and likely limit virus spread in epithelial cells [119] . Therefore, type III IFN might be induced at the end the of the stealth phase complementing the function of type I IFN. The speed at which this process occurs is controlled by the ability of the virus to suppress inflammation. This observation points out that immune modulation by the pathogen not only targets local lung immunity but also the external intervention of pre-programmed leukocytes with advantageous antiviral machinery.
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