Author: Singh, Manmeet; Khan, Reas S.; Dine, Kimberly; Das Sarma, Jayasri; Shindler, Kenneth S.
Title: Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis Document date: 2018_9_4
ID: 03c9rx3o_26_1
Snippet: e used to demonstrate resting levels of microglial staining. Iba-1 staining did not reveal any increased numbers of microglia/macrophages in optic nerve sections following intranasal viral inoculation as compared to mock-infected (Figure 4) . To confirm that lack of viral antigen detection in the optic nerve represents a failure of the virus to spread to optic nerve and retina, and not a failure to detect viral antigen, viral antigen was also exa.....
Document: e used to demonstrate resting levels of microglial staining. Iba-1 staining did not reveal any increased numbers of microglia/macrophages in optic nerve sections following intranasal viral inoculation as compared to mock-infected (Figure 4) . To confirm that lack of viral antigen detection in the optic nerve represents a failure of the virus to spread to optic nerve and retina, and not a failure to detect viral antigen, viral antigen was also examined in olfactory bulb sections from the same mice by autofluoresence of EGFP (Figures 4 J,K) as well as immunostaining with anti-viral nucleocapsid antisera (Figures 4 L,M) .
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