Author: Xu, Yingying; Yuen, Pak-Wai; Lam, Jenny Ka-Wing
Title: Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives Document date: 2014_7_10
ID: 0bma2749_15
Snippet: Conventional vaccines are usually administered by parenteral injections which mainly target the systemic immune system, eliciting only weak mucosal immune response. When the vaccines are delivered directly to the mucosal site, mucosal immune response can be more efficiently potentiated. In particular, nasal mucosa has attracted considerable attention as the site of vaccination in recent years, including DNA vaccines, due to several distinct advan.....
Document: Conventional vaccines are usually administered by parenteral injections which mainly target the systemic immune system, eliciting only weak mucosal immune response. When the vaccines are delivered directly to the mucosal site, mucosal immune response can be more efficiently potentiated. In particular, nasal mucosa has attracted considerable attention as the site of vaccination in recent years, including DNA vaccines, due to several distinct advantages. However, there are also some formidable barriers that need to be overcome to allow successful development of intranasal DNA vaccines.
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