Author: Xu, Yingying; Yuen, Pak-Wai; Lam, Jenny Ka-Wing
Title: Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives Document date: 2014_7_10
ID: 0bma2749_56
Snippet: To enhance the transfection efficiency of chitosan for intranasal administration, thiolated chitosan derivative has been introduced. Thiolated chitosan derivative has strong mucoadhesive properties due to the formation of disulphide bonds between thiol groups of the modified polymer and cysteine-rich subdomains of glycoproteins in the mucus layer, leading to an improvement in mucoadhesion of up to 140-fold when compared to unmodified chitosan [15.....
Document: To enhance the transfection efficiency of chitosan for intranasal administration, thiolated chitosan derivative has been introduced. Thiolated chitosan derivative has strong mucoadhesive properties due to the formation of disulphide bonds between thiol groups of the modified polymer and cysteine-rich subdomains of glycoproteins in the mucus layer, leading to an improvement in mucoadhesion of up to 140-fold when compared to unmodified chitosan [158] . Improved and sustained gene expression could be achieved both in vitro and in vivo with thiolated chitosan derivative [159] . This technology has a huge potential to be adopted for intranasal DNA vaccine delivery.
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