Author: Xu, Yingying; Yuen, Pak-Wai; Lam, Jenny Ka-Wing
Title: Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives Document date: 2014_7_10
ID: 0bma2749_60
Snippet: Liposomes are vesicles comprised of phospholipid bilayers. They have been extensively investigated for delivering DNA into mammalian cells as well as vaccine adjuvants. The duo functions make them an excellent carrier system for DNA vaccine [168] [169] [170] [171] . For DNA delivery, the negatively charged plasmid DNA can be absorbed to the surface of cationic liposomes through electrostatic interaction to form complexes. Alternatively, DNA can b.....
Document: Liposomes are vesicles comprised of phospholipid bilayers. They have been extensively investigated for delivering DNA into mammalian cells as well as vaccine adjuvants. The duo functions make them an excellent carrier system for DNA vaccine [168] [169] [170] [171] . For DNA delivery, the negatively charged plasmid DNA can be absorbed to the surface of cationic liposomes through electrostatic interaction to form complexes. Alternatively, DNA can be encapsulated in the aqueous core of the cationic, non-ionic or anionic liposomes. In general, transfection efficiency of cationic liposomes is superior to their non-ionic or anionic counterparts [172] , whereas anionic liposomes provided enhanced antibody responses [171] . Surfaces of the liposomes can be decorated with targeting ligands or antigenic components to improve the immune response in vaccine formulation [173] .
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