Author: Mehta, Reena; Scheffler, Margaret; Tapia, Lorena; Aideyan, Letisha; Patel, Kirtida D; Jewell, Alan M; Avadhanula, Vasanthi; Mei, Minghua; Garofalo, Roberto P; Piedra, Pedro A
Title: Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity Document date: 2014_8_12
ID: 0ow8oo82_28
Snippet: To further address this issue, we evaluated caspases 3 and 7, as caspases play a vital role in, and are biomarkers for, apoptosis. Caspases 3 and 7 are effector caspases that break down intracellular proteins and trigger the apoptotic pathway. We reasoned that children with greater NW-caspase 3/7 activity were more likely to have controlled antiviral proinflammatory responses with less severe illness. Previous studies have shown a role for both g.....
Document: To further address this issue, we evaluated caspases 3 and 7, as caspases play a vital role in, and are biomarkers for, apoptosis. Caspases 3 and 7 are effector caspases that break down intracellular proteins and trigger the apoptotic pathway. We reasoned that children with greater NW-caspase 3/7 activity were more likely to have controlled antiviral proinflammatory responses with less severe illness. Previous studies have shown a role for both granulocyte and respiratory epithelial cell apoptosis in antiviral immunity. 19 Further, some investigation has shown that incubating RSV with granulocytes inhibits apoptosis in vitro, while a study of RSV positive infants has shown increased granulocyte apoptosis in vivo. 20, 21 Other studies have highlighted that
Search related documents:
Co phrase search for related documents- antiviral immunity and proinflammatory response: 1, 2, 3, 4, 5, 6
- antiviral proinflammatory response and proinflammatory response: 1, 2, 3, 4, 5, 6, 7, 8, 9
- antiviral proinflammatory response control and proinflammatory response: 1
- apoptotic pathway and previous study: 1, 2, 3, 4
- cell apoptosis and NW caspase activity: 1
- cell apoptosis and previous study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cell apoptosis and proinflammatory response: 1, 2, 3, 4, 5
- cell apoptosis and respiratory epithelial cell apoptosis: 1, 2
- epithelial cell apoptosis and NW caspase activity: 1
- epithelial cell apoptosis and previous study: 1
- epithelial cell apoptosis and respiratory epithelial cell apoptosis: 1, 2
- intracellular protein and previous study: 1
- intracellular protein and proinflammatory response: 1
- NW caspase activity and proinflammatory response: 1
- positive infant and previous study: 1
- previous study and proinflammatory response: 1, 2
Co phrase search for related documents, hyperlinks ordered by date