Selected article for: "epithelial cell and respiratory epithelial cell"
Author: Mehta, Reena; Scheffler, Margaret; Tapia, Lorena; Aideyan, Letisha; Patel, Kirtida D; Jewell, Alan M; Avadhanula, Vasanthi; Mei, Minghua; Garofalo, Roberto P; Piedra, Pedro A
Title: Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity
  • Document date: 2014_8_12
    • ID: 0ow8oo82_28
    Snippet: To further address this issue, we evaluated caspases 3 and 7, as caspases play a vital role in, and are biomarkers for, apoptosis. Caspases 3 and 7 are effector caspases that break down intracellular proteins and trigger the apoptotic pathway. We reasoned that children with greater NW-caspase 3/7 activity were more likely to have controlled antiviral proinflammatory responses with less severe illness. Previous studies have shown a role for both g.....
    Document: To further address this issue, we evaluated caspases 3 and 7, as caspases play a vital role in, and are biomarkers for, apoptosis. Caspases 3 and 7 are effector caspases that break down intracellular proteins and trigger the apoptotic pathway. We reasoned that children with greater NW-caspase 3/7 activity were more likely to have controlled antiviral proinflammatory responses with less severe illness. Previous studies have shown a role for both granulocyte and respiratory epithelial cell apoptosis in antiviral immunity. 19 Further, some investigation has shown that incubating RSV with granulocytes inhibits apoptosis in vitro, while a study of RSV positive infants has shown increased granulocyte apoptosis in vivo. 20, 21 Other studies have highlighted that

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