Author: Mazalovska, Milena; Kouokam, J. Calvin
Title: Lectins as Promising Therapeutics for the Prevention and Treatment of HIV and Other Potential Coinfections Document date: 2018_5_8
ID: 0spmy8vn_16
Snippet: Longispora albida [40] . The protein is a single polypeptide with a molecular weight of 12.5 kDa and 114 amino acids that form three sugar-binding pockets with LD-QXW motifs [28] . These three segments are highly conserved and necessary for both B-and T-tropic antisyncytium formation activity [41] . Tanaka et al. reported that AH specifically binds to high-mannose-type glycans [37] . Additionally, AH has been shown to have affinity only to glycop.....
Document: Longispora albida [40] . The protein is a single polypeptide with a molecular weight of 12.5 kDa and 114 amino acids that form three sugar-binding pockets with LD-QXW motifs [28] . These three segments are highly conserved and necessary for both B-and T-tropic antisyncytium formation activity [41] . Tanaka et al. reported that AH specifically binds to high-mannose-type glycans [37] . Additionally, AH has been shown to have affinity only to glycoproteins with multiple high-mannose glycans, unlike CV-N which can bind a single high-mannose glycan attached to a protein. Also unlike CV-N, AH does not show cytopathic or mitogenic effects. Based on previous studies AH has the potential to be developed as a microbicide drug since it can effectively inhibit HIV-1 and HIV-2 with low IC50 values (2-110 nM), block syncytium formation, and display neutralization activity against laboratory-adapted strains with minimal variation in antiviral activity [42] .
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