Author: Mazalovska, Milena; Kouokam, J. Calvin
Title: Lectins as Promising Therapeutics for the Prevention and Treatment of HIV and Other Potential Coinfections Document date: 2018_5_8
ID: 0spmy8vn_7
Snippet: HIV-1 entry into target cells is mediated by binding of its envelope glycoprotein to cell surface receptors. The envelope glycoprotein gp160 is originally synthesized as a single, glycosylated, polyprotein precursor, which is then cleaved by a cellular protease to yield two subunits, including gp120 (responsible for viral binding to CD4 receptor and a coreceptor, namely, CCR5 or CXR4) and gp41, which mediate viral fusion to the cell [23] . HIV us.....
Document: HIV-1 entry into target cells is mediated by binding of its envelope glycoprotein to cell surface receptors. The envelope glycoprotein gp160 is originally synthesized as a single, glycosylated, polyprotein precursor, which is then cleaved by a cellular protease to yield two subunits, including gp120 (responsible for viral binding to CD4 receptor and a coreceptor, namely, CCR5 or CXR4) and gp41, which mediate viral fusion to the cell [23] . HIV uses gp120 to bind C-type lectin receptor (CLR) on macrophages as well as DC-SIGN, a C-type mannose-specific lectin, expressed by dendritic cells [24] .
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