Selected article for: "high mutation rate and mutation rate"
Author: Barker, Emily N.; Stranieri, Angelica; Helps, Chris R.; Porter, Emily L.; Davidson, Andrew D.; Day, Michael J.; Knowles, Toby; Kipar, Anja; Tasker, Séverine
Title: Limitations of using feline coronavirus spike protein gene mutations to diagnose feline infectious peritonitis
  • Document date: 2017_10_5
    • ID: 08b0g46x_67
    Snippet: False-negative FCoV RT-qPCR results are possible, due to the high rate of FCoV genomic mutation, which could result in inefficient binding at the primer and/or probe sites. As only samples with FCoV RT-qPCR-positive results had pyrosequencing performed, FCoV RT-qPCRnegative results were not confirmed. However, false negative RT-qPCR results are considered to be uncommon, and were only detected in 1 of 57 cats with confirmed FIP in this study wher.....
    Document: False-negative FCoV RT-qPCR results are possible, due to the high rate of FCoV genomic mutation, which could result in inefficient binding at the primer and/or probe sites. As only samples with FCoV RT-qPCR-positive results had pyrosequencing performed, FCoV RT-qPCRnegative results were not confirmed. However, false negative RT-qPCR results are considered to be uncommon, and were only detected in 1 of 57 cats with confirmed FIP in this study where at least one tissue from all the other cats were positive.

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