Author: Palmer, Duncan S.; Turner, Isaac; Fidler, Sarah; Frater, John; Goedhals, Dominique; Goulder, Philip; Huang, Kuan-Hsiang Gary; Oxenius, Annette; Phillips, Rodney; Shapiro, Roger; Vuuren, Cloete van; McLean, Angela R.; McVean, Gil
Title: Mapping the drivers of within-host pathogen evolution using massive data sets Document date: 2019_7_9
ID: 100r7w2n_127
Snippet: A * 02 epitope YTAFTIPSV (sites 127-135 in reverse transcriptase). We do not detect A * 02-associated selection in YTAFTIPSV. The subtype B and C consensus residue at the escape site (position 135) is the defined escape allele [41] , explaining why we do not detect a signal. However, we notice that a signal at the escape site is picked up when considering subtype B viruses (see the fifth and sixth A * 02 strips of Supplementary Figure 17 ). This .....
Document: A * 02 epitope YTAFTIPSV (sites 127-135 in reverse transcriptase). We do not detect A * 02-associated selection in YTAFTIPSV. The subtype B and C consensus residue at the escape site (position 135) is the defined escape allele [41] , explaining why we do not detect a signal. However, we notice that a signal at the escape site is picked up when considering subtype B viruses (see the fifth and sixth A * 02 strips of Supplementary Figure 17 ). This suggests that other mutations at the same residue can also result in a diminished CTL response.
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