Selected article for: "escape site selection detect and selection detect"
Author: Palmer, Duncan S.; Turner, Isaac; Fidler, Sarah; Frater, John; Goedhals, Dominique; Goulder, Philip; Huang, Kuan-Hsiang Gary; Oxenius, Annette; Phillips, Rodney; Shapiro, Roger; Vuuren, Cloete van; McLean, Angela R.; McVean, Gil
Title: Mapping the drivers of within-host pathogen evolution using massive data sets
  • Document date: 2019_7_9
    • ID: 100r7w2n_133
    Snippet: Finally, looking at Supplementary Figure 14 we see that A * 02-dependent selection is detected in LVGPTPVNI, but not at the reported escape site. We detect strong selection at the first anchor residue, and slightly upstream of the epitope. Interestingly, some literature suggests that the wild type sequence is not recognised, and a drug induced mutation at the escape site (position 82) results in epitope recognition [44] . These conflicting signal.....
    Document: Finally, looking at Supplementary Figure 14 we see that A * 02-dependent selection is detected in LVGPTPVNI, but not at the reported escape site. We detect strong selection at the first anchor residue, and slightly upstream of the epitope. Interestingly, some literature suggests that the wild type sequence is not recognised, and a drug induced mutation at the escape site (position 82) results in epitope recognition [44] . These conflicting signals may explain why we do not detect A * 02-associated selection at the known escape site.

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