Author: Yang, Liu; Du, Xing; Liu, Lu; Cao, Qiuyu; Pan, Zengxiang; Li, Qifa
Title: miR-1306 Mediates the Feedback Regulation of the TGF-ß/SMAD Signaling Pathway in Granulosa Cells Document date: 2019_3_31
ID: 16qix4ab_54
Snippet: In conclusion, we proved that the pro-apoptotic factor miR-1306 controls porcine GC apoptosis by targeting TGFBR2 and inactivating the TGF-β/SMAD signaling pathway. Our findings pave the way for a potential non-hormonal target or drug therapy candidate for improving female fertility. Moreover, the transcription factor SMAD4 was identified as a transcriptional regulator of the exonic miR-1306, but this process is not independent of its host gene .....
Document: In conclusion, we proved that the pro-apoptotic factor miR-1306 controls porcine GC apoptosis by targeting TGFBR2 and inactivating the TGF-β/SMAD signaling pathway. Our findings pave the way for a potential non-hormonal target or drug therapy candidate for improving female fertility. Moreover, the transcription factor SMAD4 was identified as a transcriptional regulator of the exonic miR-1306, but this process is not independent of its host gene DGCR8. Our findings also reveal a feedback mechanism of the classical TGF-β/SMAD signaling pathway ( Figure 6D ) and provide novel insights into feedback regulation within the classical TGF-β/SMAD signaling pathway.
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