Author: Stark, Caren J; Atreya, CD
Title: Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies Document date: 2005_4_15
ID: 0fitbwuv_10
Snippet: RNA viruses utilize a variety of mechanisms to exchange their genetic repertoire. The viral RNA dependent RNA polymerases (RdRP) have a built in error rate that allows diversification of the genomic sequence as replication proceeds. Estimates put the error rate of an RdRp at 10 -3 to 10 -5 per nucleotide [30] . Coronaviruses also undergo high rates of RNA recombination, providing an additional mechanism by which the viruses can rapidly amplify ge.....
Document: RNA viruses utilize a variety of mechanisms to exchange their genetic repertoire. The viral RNA dependent RNA polymerases (RdRP) have a built in error rate that allows diversification of the genomic sequence as replication proceeds. Estimates put the error rate of an RdRp at 10 -3 to 10 -5 per nucleotide [30] . Coronaviruses also undergo high rates of RNA recombination, providing an additional mechanism by which the viruses can rapidly amplify genomic diversity. The SARS-CoV polymerase gene has a recombination breakpoint, suggesting multiple genetic origins for this molecule. [31] . These evolutionary mechanisms may have facilitated the adaptation of the animalborne SARS-CoV ancestor to the human host, suggesting that such events in the future could lead to a virus with increased pathogenicity for humans or one capable of infecting multiple species. Recent evidence indicates that the human-adapted SARS virus has crossed into another species. Sequence and epidemiological analyses revealed that a SARS-CoV isolated from a pig was derived from a human strain. Complete nucleotide sequencing of the pig virus isolate (designated TJF) and an S gene-based phylogenetic tree analysis revealed a closer relationship with human SARS-CoV isolates than with animal coronaviruses [32] .
Search related documents:
Co phrase search for related documents- dependent RNA polymerase and tree analysis: 1, 2
- dependent RNA polymerase and viral RNA RdRP dependent RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- error rate and tree analysis: 1
- error rate and viral RNA RdRP dependent RNA polymerase: 1
- gene base and tree analysis: 1, 2
- high rate and viral RNA RdRP dependent RNA polymerase: 1, 2, 3, 4, 5
- human host and viral RNA RdRP dependent RNA polymerase: 1, 2, 3
- phylogenetic tree analysis and viral RNA RdRP dependent RNA polymerase: 1
- polymerase gene and viral RNA RdRP dependent RNA polymerase: 1, 2, 3, 4, 5
- RdRP dependent RNA polymerase and viral RNA RdRP dependent RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- RdRp error rate and viral RNA RdRP dependent RNA polymerase: 1
- recent evidence and viral RNA RdRP dependent RNA polymerase: 1
- RNA polymerase and viral RNA RdRP dependent RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- RNA RdRP dependent RNA polymerase and viral RNA RdRP dependent RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- RNA recombination and viral RNA RdRP dependent RNA polymerase: 1, 2, 3
- RNA virus and viral RNA RdRP dependent RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36
- SARS CoV polymerase gene and viral RNA RdRP dependent RNA polymerase: 1
- SARS virus and viral RNA RdRP dependent RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- tree analysis and viral RNA RdRP dependent RNA polymerase: 1
Co phrase search for related documents, hyperlinks ordered by date