Author: Lau, Susanna K. P.; Wong, Antonio C. P.; Lau, Terrence C. K.; Woo, Patrick C. Y.
Title: Molecular Evolution of MERS Coronavirus: Dromedaries as a Recent Intermediate Host or Long-Time Animal Reservoir? Document date: 2017_10_16
ID: 1sq2uvur_8
Snippet: The 219 complete genomes of MERS-CoV were clustered into two major clades, A and B ( Figure 2 ). Most MERS-CoV strains belong to clade B, while clade A only contains five strains. Clade A is further divided into two lineages: lineage A1, with three human strains, one being the first MERS-CoV strain isolated from the index 60-year-old male patient from Bisha, Saudi Arabia in September 2012, and the other two from Jordan; and lineage A2, with two .....
Document: The 219 complete genomes of MERS-CoV were clustered into two major clades, A and B ( Figure 2 ). Most MERS-CoV strains belong to clade B, while clade A only contains five strains. Clade A is further divided into two lineages: lineage A1, with three human strains, one being the first MERS-CoV strain isolated from the index 60-year-old male patient from Bisha, Saudi Arabia in September 2012, and the other two from Jordan; and lineage A2, with two camel strains, one from the UAE and the other from Egypt. Clade B is further divided into six lineages. Both human and camel strains were present in most lineages. Lineage B1 is dominated by MERS-CoV strains from the UAE, whereas lineages B2 to B6 are mainly dominated by strains from Saudi Arabia. Lineage 3 consists of the largest number of strains, including the human strains from an outbreak in South Korea, which occurred as a result of acquisition of MERS-CoV by a Korean who visited multiple Middle East countries, including Bahrain, Qatar, Saudi Arabia, and the UAE from 24 April to 4 May 2015 and subsequent
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