Author: Perra, Léa; Balloy, Viviane; Foussignière, Tobias; Moissenet, Didier; Petat, Hortense; Mungrue, Imran N.; Touqui, Lhousseine; Corvol, Harriet; Chignard, Michel; Guillot, Loic
Title: CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by Pseudomonas aeruginosa Document date: 2018_11_29
ID: 10fe70kl_38
Snippet: (25) pathways. In our previous study, we identified the CHAC1 mRNA as one of the most highly differentially expressed transcripts between primary bronchial cells from CF and non-CF patients, infected with Pa. We also found that CF cells exhibited an expected excessive inflammatory response, including higher IL-8 production (10). Because CHAC1 was recently described as a new component of the UPR in the PERK pathway (12), we aimed to evaluate wheth.....
Document: (25) pathways. In our previous study, we identified the CHAC1 mRNA as one of the most highly differentially expressed transcripts between primary bronchial cells from CF and non-CF patients, infected with Pa. We also found that CF cells exhibited an expected excessive inflammatory response, including higher IL-8 production (10). Because CHAC1 was recently described as a new component of the UPR in the PERK pathway (12), we aimed to evaluate whether CHAC1 was involved in the modulation of the inflammatory response induced by Pa in lung epithelial cells.
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