Selected article for: "cava ethanol extract and ethanol extract"
Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review
  • Document date: 2019_6_18
    • ID: 0dpv85od_145
    Snippet: The regulation of blood pressure involves angiotensin-converting enzyme (ACE), a potent vasoconstrictor, whose role is to convert angiotensin I to angiotensin II. Hence, ACE inhibition plays a physiological role in the treatment of hypertension. Natural ACE inhibitors as alternatives with fewer side effects as compared to synthetic drugs have been a major interest for research in preventing hypertension [118] . Among the ethanol, EtOAc, chlorofor.....
    Document: The regulation of blood pressure involves angiotensin-converting enzyme (ACE), a potent vasoconstrictor, whose role is to convert angiotensin I to angiotensin II. Hence, ACE inhibition plays a physiological role in the treatment of hypertension. Natural ACE inhibitors as alternatives with fewer side effects as compared to synthetic drugs have been a major interest for research in preventing hypertension [118] . Among the ethanol, EtOAc, chloroform, hexane, and diethyl ether extracts of E. cava, the strongest ACE inhibitory activity was demonstrated by the ethanol extract (IC 50 0.96 mg/mL). The ethanol extract consisted of phlorotannins which exhibited potent ACE inhibition: phloroglucinol (IC 50 2.57 ± 0.09 mM), triphlorethol-A (IC 50 2.01 ± 0.36 mM), eckol (IC 50 2.27 ± 0.08 mM), dieckol (IC 50 1.47 ± 0.04 mM), and dioxinodehydroeckol (IC 50 2.95 ± 0.28 mM). Eckol showed lower IC 50 than that of the weakest dioxinodehydroeckol. The protein-binding abilities of the phlorotannins occurring reversibly by hydrogen bonding or irreversibly through covalent condensations could be associated with the ACE inhibition [119] .

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