Selected article for: "µg ml and cava extract"
Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review
  • Document date: 2019_6_18
    • ID: 0dpv85od_155
    Snippet: Similarly, viral hemorrhagic septicemia virus (VHSV) in the fathead minnow (FHM) cell line was used to test the inhibition efficacy of E. cava extract and its compounds. At low concentrations of 10 µg/mL, the extract, eckol, and phlorofucofuroeckol-A exhibited potent virus inhibitory activity. When there was simultaneous co-exposure of VHSV to extract, eckol, and phlorofucofuroeckol-A in the FHM, the inhibition rates increased (46.4-96.4% ) as c.....
    Document: Similarly, viral hemorrhagic septicemia virus (VHSV) in the fathead minnow (FHM) cell line was used to test the inhibition efficacy of E. cava extract and its compounds. At low concentrations of 10 µg/mL, the extract, eckol, and phlorofucofuroeckol-A exhibited potent virus inhibitory activity. When there was simultaneous co-exposure of VHSV to extract, eckol, and phlorofucofuroeckol-A in the FHM, the inhibition rates increased (46.4-96.4% ) as compared to the pre-(16.5-48.4%) and post-exposure (39.5-56.5%) strategies with the EC 50 values of 4.76, 1.97, and 0.99 µg/mL for the extract, eckol, and phlorofucofuroeckol-A, respectively. Also, an increase in the exposure time led to high activity against the virus in the FHM cell line. After the oral administration of the extract to the olive flounder challenged with VHSV, the efficacy against VHSV resulted according to the VHSV challenge concentration and the dose of extract. The increase in proinflammatory cytokines (IL-1β, IL-6, and IFN-γ) expression and the activation of IFN-α/β, ISG15, and Mx indicated the immunomodulatory and immunostimulatory effect of the extract [67] .

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