Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review Document date: 2019_6_18
ID: 0dpv85od_173
Snippet: Eckol and its derivatives were evaluated for their barrier protective effects against proinflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice. According to the results, the eckol and dieckol isolated from E. bicyclis showed inhibition of barrier disruption mediated by LPS and trans-endothelial migration of leukocytes to human endothelial cells at a concentration of 10 µM. In addition, eckol inhibited acetic acid-.....
Document: Eckol and its derivatives were evaluated for their barrier protective effects against proinflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice. According to the results, the eckol and dieckol isolated from E. bicyclis showed inhibition of barrier disruption mediated by LPS and trans-endothelial migration of leukocytes to human endothelial cells at a concentration of 10 µM. In addition, eckol inhibited acetic acid-induced hyperpermeability and leukocyte migration induced by carboxymethylcellulose-sodium in vivo. Interestingly, according to the results obtained, the hydrogen donating hydroxyl groups present in dieckol regulated its protection ability which was better than eckol [69] .
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