Author: McCarthy, Mary K.; Reynoso, Glennys V.; Winkler, Emma S.; Mack, Matthias; Diamond, Michael S.; Hickman, Heather D.; Morrison, Thomas E.
Title: MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2 Document date: 2020_1_30
ID: 1tut4erh_7
Snippet: In this study, we find that a MyD88-dependent influx of monocytes and neutrophils to the dLN disrupts structural organization, impairs lymphocyte accumulation, and diminishes downstream antiviral B cell responses to pathogenic CHIKV infection in a manner partially dependent on expression of inducible nitric oxide synthase (iNOS) and the phagocyte NADPH oxidase (Nox2). We also identify a role for local IRF5-driven type I IFN signaling in the dLN t.....
Document: In this study, we find that a MyD88-dependent influx of monocytes and neutrophils to the dLN disrupts structural organization, impairs lymphocyte accumulation, and diminishes downstream antiviral B cell responses to pathogenic CHIKV infection in a manner partially dependent on expression of inducible nitric oxide synthase (iNOS) and the phagocyte NADPH oxidase (Nox2). We also identify a role for local IRF5-driven type I IFN signaling in the dLN that is triggered by TLR7 and one or more additional TLR(s) and promotes iNOS expression in infiltrating monocytes. Overall, our data suggest that the rapid, early influx of monocytes and neutrophils detrimentally impacts the B cell response to pathogenic CHIKV infection through a novel IRF5-dependent mechanism.
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