Author: Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue
Title: Characterizing Eckol as a Therapeutic Aid: A Systematic Review Document date: 2019_6_18
ID: 0dpv85od_174
Snippet: Similarly, the signaling pathways involved in the protective actions of eckol and dieckol, including phloroglucinol, against pro-inflammatory responses in HUVECs and in high-mobility group box 1 (HMGB1) protein-treated mice were investigated. These phlorotannins inhibited LPS (100 ng/mL)-induced HMGB1 release and the expression of Toll-like receptor 4. In addition, they also inhibited barrier disruption medidated by HMGB1, the expression of cell .....
Document: Similarly, the signaling pathways involved in the protective actions of eckol and dieckol, including phloroglucinol, against pro-inflammatory responses in HUVECs and in high-mobility group box 1 (HMGB1) protein-treated mice were investigated. These phlorotannins inhibited LPS (100 ng/mL)-induced HMGB1 release and the expression of Toll-like receptor 4. In addition, they also inhibited barrier disruption medidated by HMGB1, the expression of cell adhesion molecules (CAMs) (VCAM-1, ICAM-1 and E-selectin) and trans-endothelial migration of leukocytes to human endothelial cells. In addition, they suppressed hyperpermeability induced by acetic-acid and leukocyte migration induced by carboxymethylcellulose in vivo. To further explain the importance of hydroxyl group for the protective action, a change with the methyl group at the hydroxyl position of dieckol, diminished the vascular barrier protective effects [24] .
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