Characterizing Eckol as a Therapeutic Aid: A Systematic Review

Manandhar, Bandana; Paudel, Pradeep; Seong, Su Hui; Jung, Hyun Ah; Choi, Jae Sue

In another study, the protective effect of eckol was linked to anti-hearing loss activity by preventing the temporary threshold shift (TTS). The implications of noise-induced hearing loss (NIHL) has received a lot of consideration among teenagers in recent years. Temporary threshold shift, which is a type of NIHL, accelerates the age-related hearing loss even if it is a transient one. As the primary cause of TTS is ROS, the protective activity of polyphenolic extract of E. cava (PPEE) was evaluated which resulted in decreased ROS levels. The notable compounds in PPEE were typical polyphenols found in E. cava which included dieckol (16.8%), phlorofucofuroeckol-A (3.5%), and eckol (1.9%), contributing to its anti-oxidant potential. The intraperitoneal administration of PPEE (100 mg/kg) and saline to the mice with exposure to noise significantly decreased the auditory brainstem response threshold shifts and provided a significant degree of protection in relation to the distortion product otoacoustic emission levels. Thus, eckol containing PPEE may have good potential to break the vicious cycle of TTS [150] .