Author: Li, Xiao-Jun; Kim, Kwan-Woo; Oh, Hyuncheol; Liu, Xiang-Qian; Kim, Youn-Chul
Title: Chemical Constituents and an Antineuroinflammatory Lignan, Savinin from the Roots of Acanthopanax henryi Document date: 2019_2_21
ID: 1vbkttzx_29
Snippet: Cells. Inhibition of iNOS and COX-2 protein expression could be an important strategy to prevent neuroinflammation. In the present study, it was investigated whether compound inhibits LPS-induced overexpression of iNOS and COX-2 protein in BV2 cells. BV2 cells were pretreated with compound for 3 h and stimulated with LPS (1 g/mL) for 24 h. As a result, LPS augmented the expression of iNOS and COX-2 proteins; however, pretreatment with compound re.....
Document: Cells. Inhibition of iNOS and COX-2 protein expression could be an important strategy to prevent neuroinflammation. In the present study, it was investigated whether compound inhibits LPS-induced overexpression of iNOS and COX-2 protein in BV2 cells. BV2 cells were pretreated with compound for 3 h and stimulated with LPS (1 g/mL) for 24 h. As a result, LPS augmented the expression of iNOS and COX-2 proteins; however, pretreatment with compound reversed these responses (Figure 2 ).
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